microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report

• DOI: 10.1007/s13277-013-0748-5
• Publication Date: 2013-04-04T04:14:16Z
• Authors: Magdalena Kowalewska; Elwira Bakula-Zal...; Magdalena Chechli...; Krzysztof Goryca; Anna Nasierowska-...; Anna Danska-Bidzi...; Mariusz Bidzinski
• Keywords: Uterine sarcoma

Uterine sarcomas and mixed epithelial–mesenchymal uterine tumors are a heterogeneous group of rare for which there very few diagnostic markers available. As aberrant microRNA (miRNA) expression patterns represent putative cancer markers, we aimed to identify miRNA profiles the major sarcoma subtypes uterus. Eighty-eight miRNAs were assessed by quantitative RT-PCR in cancerous non-cancerous tissue samples collected from 29 patients with endometrial sarcoma, leiomyosarcoma, tumors. Tumor control significantly (P < 0.05) differed miR-23b, miR-1, let-7f, let-7c sarcomas, let-7c, miR-133b, let-7b, miR-143, let-7a, let-7d, let-7e, let-7g, miR-222, let-7i, miR-214 All changed down-regulated malignant tissues as compared their normal counterparts. This may suggest tumor suppressor role these malignancies. No statistically significant changes levels found between leiomyosarcoma controls. The identified warrant further studies valuable candidate differential diagnosis benign lesions subtypes.