Reduced succinate dehydrogenase B expression is associated with growth and de-differentiation of colorectal cancer cells

• DOI: 10.1007/s13277-013-0781-4
• Publication Date: 2013-05-04T05:25:27Z
• Authors: Decai Zhang; Wei Wang; Bo Xiang; Nan Li; Shuo Huang; Weiwei Zhou; Yingnan Sun; Xiaoyan Wang; Jian Ma; Guiyuan Li; Xiayu Li; Shourong Shen
• Keywords: SDHB; SDHD; SDHA; Tissue microarray

Succinate dehydrogenases (SDH), including SDHA, SDHB, SDHC, and SDHD, form the respiratory complex II in mitochondria play an important role cell growth homeostasis. In order to evaluate expression functional significance of SDH colorectal cancer, four subunits was analyzed, SDHB protein found be significantly lower cancer tissues. vitro experiments assay, colony formation cycle analysis, nude mouse xenograft SDHB-transfected line SW620 were performed. Notably, reduced tumor tissues associated with de-differentiation, restoration could inhibit cells both vivo. Furthermore, cDNA microarray showed that most differentially expressed genes are related control proliferation. Thus, we conclude is decreased human tissues, reconstitution may a potential therapeutic approach aggressiveness cancer.