Clinical significance of serum insulin-like growth factor-1 (IGF-1) and insulinlike growth factor binding protein-3 (IGFBP-3) in patients with epithelial ovarian cancer

• DOI: 10.1007/s13277-013-1405-8
• Publication Date: 2013-11-19T12:11:02Z
• Authors: Faruk Tas; Senem Karabulut; Murat Serilmez; Rumeysa Ciftci; Derya Duranyildiz
• Keywords: Clinical Significance

Insulin-like growth factor-1 (IGF-1) and its primary binding protein IGFBP-3 play an important role in cellular proliferation, differentiation, apoptosis many tumors, including ovarian cancer. The objective of this study was to determine the clinical significance serum levels IGF-1 epithelial cancer (EOC) patients. A total 50 patients with a pathologically confirmed diagnosis EOC were enrolled into study. Serum determined by solid-phase sandwich ELISA method. Twenty age- sex-matched healthy controls included analysis. Median age 56.5 years old (range 22 83 years). Majority had advanced disease (FIGO stage III-IV; 90%). No significant difference observed baseline between (p = 0.99 p 0.80, respectively). young higher concentrations 0.04 0.02, Patients normal CA-125 compared those 0.008). However, no other variables histology, tumor grade, disease, response chemotherapy found be correlated IGF assays > 0.05). trend relationship (r(s) 0.212, 0.07). elevated favorable progression-free overall survivals than lower 0.03, have prognostic for both 0.12 0.26, In conclusion, level is associated