Aberrant BLID expression is associated with breast cancer progression

• DOI: 10.1007/s13277-014-1710-x
• Publication Date: 2014-02-17T15:23:32Z
• Authors: Xiaoyan Li; Peng Su; Xianqiang Liu; Xiangnan Kong; Xin Zhang; Hongyu Zhang; Qifeng Yang
• Keywords: Adult; 03 medical and health sciences; 0302 clinical medicine; Disease Progression; Humans; Breast Neoplasms; Female; Middle Aged; Apoptosis Regulatory Proteins; Aged; 3. Good health

In our previous study, we have found that BH3-like motif containing, cell death inducer (BLID) was a tumor suppressor in breast cancer, and its downregulation was correlated with both poor disease-free and overall survival. In the present study, we aimed to explore the possible role of BLID in breast cancer progression. We found that BLID was strongly expressed in all normal breast tissues, and it became lower and wreaker gradually in the progression from normal, UDH (usual ductal hyperplasia), ADH (atypical ductal hyperplasia), and DCIS (ductal carcinoma in situ) to breast cancer. Statistical analysis demonstrated significant different BLID expressions between proliferative and cancerous breast lesions. Our data suggested that loss of BLID may contribute to the progression of intraductal proliferation lesions to breast cancer. Our finding gives a new clue that BLID might be a potential indicator for progression of breast cancer in the future.