Retinoic acid receptor-related receptor alpha (RORalpha) is a prognostic marker for hepatocellular carcinoma

• DOI: 10.1007/s13277-014-2007-9
• Publication Date: 2014-05-05T07:43:34Z
• Authors: Rong-Dang Fu; Chun-Hui Qiu; Hu-An Chen; Zhi-Gang Zhang; Min-Qiang Lu
• Keywords: Adult; Male; 0301 basic medicine; Carcinoma, Hepatocellular; Liver Neoplasms; Nuclear Receptor Subfamily 1, Group F, Member 1; Middle Aged; Prognosis; 3. Good health; 03 medical and health sciences; Biomarkers, Tumor; Humans; Female; alpha-Fetoproteins; Tumor Suppressor Protein p53; Aged

Retinoic acid receptor-related receptor alpha (RORalpha) has been proven to play a tumor suppressive role in certain types of solid tumors. However, the clinical characteristic RORalpha not reported by far. This study investigated expression hepatocellular carcinoma (HCC) and evaluated its relationship with parameters prognosis HCC patients. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) Western blot analyses were performed detect levels 20 paired corresponding adjacent non-cancerous tissues. Immunohistochemistry was on 100 archived paraffin-embedded samples. Statistical correlations between clinicopathological features. qRT-PCR showed that mRNA significantly down-regulated tumors compared tissues, blots found protein also reduced Immunohistochemical assays revealed decreased present 65 % Correlation correlated serum fetoprotein (AFP, p = 0.005), pathology grade (p < 0.001), recurrence 0.008), vascular invasion 0.001). Kaplan-Meier analysis patients low had shorter overall disease-free survival than high 0.001 0.002, respectively). Multivariate regression indicated an independent predictor for survival. In conclusion, results our associated poorer may be new potential prognostic marker