Plasma long noncoding RNA protected by exosomes as a potential stable biomarker for gastric cancer

• DOI: 10.1007/s13277-014-2807-y
• Publication Date: 2014-11-14T16:02:54Z
• Authors: Qier Li; Yongfu Shao; Xinjun Zhang; Tuo Zheng; Min Miao; Lijun Qin; Bojun Wang; Guoliang Ye; Bingxiu Xiao; Junming Guo
• Keywords: Blood plasma

Long intergenic non-protein-coding RNA 152 (LINC00152) is one of the long noncoding RNAs (lncRNAs) abnormally expressed in gastric cancer tissues. However, its value diagnosis unclear. The aim this study to evaluate clinical significance plasma LINC00152 as a biomarker screening and explore possible mechanism underling stable existence blood. We analyzed levels patients with epithelial dysplasia healthy controls using quantitative reverse transcription polymerase chain reaction then confirmed by sequencing. also compared paired preoperative postoperative samples. In addition, we exosomes, which were extracted from same transmission electron microscopy. significantly elevated controls. sensitivity specificity 48.1 85.2 %, respectively. There no significant differences between samples lower than those ones. exosomes. All these results suggested that can be detected plasma, mechanisms blood was protected It has possibility applied novel blood-based biomarker.