Microlocalization of CD68+ tumor-associated macrophages in tumor stroma correlated with poor clinical outcomes in oral squamous cell carcinoma patients

• DOI: 10.1007/s13277-015-3189-5
• Publication Date: 2015-02-10T07:45:05Z
• Authors: Yan-Hong Ni; Liang Ding; Xiao-Feng Huang; Ying-chun Dong; Qin-Gang Hu; Ya-Yi Hou
• Keywords: CD68

CD68 has been widely used as a pan-macrophage marker for tumor-associated macrophages (TAM) which always involve in carcinogenesis. But the correlations between CD68(+) TAMs and prognosis of patients show to be inconsistent, might due lack specific markers TAMs. We here found that microlocalization also played unique role with oral squamous cell carcinoma (OSCC). were identified paraffin-embedded OSCC specimens (n = 91) by using immunohistochemistry. The number was remarkably increased from adjacent none-neoplasia tissues (NT) tumor nest (TN), but stroma (TS) infiltrated highest frequency (P < 0.0001). Unexpectedly, more TS, not NT or TN, associated high grade 0.033), lymph node metastasis 0.034), shorter 10-year overall survival time, disease free survival. Considering derived monocytes peripheral blood, we assessed relationship leukocytes blood TS accompanied decreased lymphocytes 0.05). Although Cox regression analysis revealed an independent prognostic factor patients, raised possibility indispensable advance OSCC.