Differential expression of the UGT1A family of genes in stomach cancer tissues

• DOI: 10.1007/s13277-015-3253-1
• Publication Date: 2015-02-24T14:00:21Z
• Authors: Beyhan Cengiz; Onder Yumrutas; Esra Bozgeyik; Ersin Borazan; Yusuf Ziya Igci; Ibrahim Bozgeyik; Serdar Oztuzcu
• Keywords: Stomach cancer

Uridine 5′-diphospho-glucuronosyltransferases (UGT) are the key players in biotransformation of drugs, xenobiotics, and endogenous compounds. Particularly, UDP-glucuronosyltransferase 1A (UGT1A) participates a wide range biological pharmacological processes plays critical role conjugation exogenous components. Thirteen alternative splicing products were produced from UGT1A gene locus designated as UGT1A1 UGT1A3–10. A growing amount evidence suggests that they have important roles carcinogenesis which is well documented by colon, liver, pancreas, kidney cancer studies. Here, we report differential expressions genes normal tumor tissues stomach patients. Total numbers 49 patients enrolled for this study, expression analysis was evaluated real-time PCR method. Accordingly, UGT1A1, UGT1A8, UGT1A10 found to be upregulated, UGT1A3, UGT1A5, UGT1A7, UGT1A9 downregulated tumors. No changes observed UGT1A4. Also, UGT1A6 transcription variants significantly upregulated compared tissue. Additionally, UGT1A7 showed highest both tumoral tissues, interestingly, reduced stage II other In conclusion, differentially expressed these may affect development progression various types including stomach.