Downregulation of FOXP2 promoter human hepatocellular carcinoma cell invasion

• DOI: 10.1007/s13277-015-3701-y
• Publication Date: 2015-07-04T18:14:14Z
• Authors: Xia Yan; Huiling Zhou; Tingting Zhang; Pan Xu; Shusen Zhang; Wei Huang; Linlin Yang; Xingxing Gu; Runzhou Ni; Tianyi Zhang
• Keywords: FOXP2

Hepatocellular carcinoma (HCC) is a major health concern with high morbidity and mortality rate worldwide. However, the mechanism underlying hepatocarcinogenesis remains unclear. Forkhead box P2 (FOXP2) has been implicated in various human cancer types. role of FOXP2 HCC unknown. Western blot immunohistochemistry were used to measure expression protein adjacent normal tissues 50 patients. Wound healing transwell assays determine cell invasion ability. We showed that level was significantly reduced compared non-tumorous tissue. There statistical significance between vein (P = 0.017), number tumor nodes 0.028), AFP 0.033). Low correlated poor survival. Moreover, wound could decrease affect vimentin E-cadherin. Our results suggested downregulated tissues, associated overall In addition, downregulation enhanced invasiveness. These findings uncover might be new prognostic factor closely invasion.