Evaluation of GWAS-identified SNPs at 6p22 with neuroblastoma susceptibility in a Chinese population

• DOI: 10.1007/s13277-015-3936-7
• Publication Date: 2015-08-25T05:09:24Z
• Authors: Jing He; Ruizhong Zhang; Yan Zou; Jinhong Zhu; Tianyou Yang; Fenghua Wang; Huimin Xia
• Keywords: Genome-wide Association Study

Previous genome-wide association studies (GWASs) have reported that three single nucleotide polymorphisms (SNPs) (rs6939340 A>G, rs4712653 T>C, and rs9295536 C>A) located at 6p22 locus were associated with neuroblastoma susceptibility for Caucasian descent. We conducted this hospital-based case-control study 201 patients 531 controls to investigate the between these SNPs in FLJ22536 gene Chinese Han population. The odds ratio (OR) 95 % confidence interval (CI) calculated estimate strength of using unconditional logistic regression model. found rs6939340 A allele carriers significantly decreased (AG vs. GG: adjusted OR = 0.54, CI 0.38–0.77; AA 0.49, 0.25–0.93; AA/AG 0.53, 0.38–0.74) after adjustment age gender. protective variant was also observed polymorphisms. Moreover, we subjects carrying one or more genotypes had a much lower than non-carriers (adjusted 0.60, 0.43–0.83). Our verified associations all are subjects. Further prospective multicenter different ethnicities larger sample size needed validate our findings.