Pituitary tumor-transforming gene 1 enhances metastases of cervical cancer cells through miR-3666-regulated ZEB1

• DOI: 10.1007/s13277-015-4047-1
• Publication Date: 2015-09-17T20:42:56Z
• Authors: Lin Li; Li-Ying Han; Ming Yu; Qi Zhou; Jian-Cheng Xu; Ping Li
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Early cancer metastases often occur in cervical (CC) patients, resulting poor prognosis and therapeutic outcome after resection of primary cancer. Hence, there is a compelling requirement for elucidating the molecular mechanisms underlying CC cell invasiveness. Recently, role microRNAs (miRNAs) pituitary tumor-transforming gene 1 (Pttg1) carcinogenesis has been reported. Nevertheless, relationship between miRNAs Pttg1 remains ill-defined. Here, we showed that levels miR-3666 were significantly decreased zinc finger E-box binding homeobox (ZEB1) increased specimens from compared to paired non-tumor tissue. Moreover, ZEB1 inversely correlated. Bioinformatics analyses targeted 3′-untranslated region (3′-UTR) messenger RNA (mRNA) inhibit its translation, which was confirmed by luciferase reporter assay. overexpression inhibited subsequently invasion, while depletion invasion. Together, our data suggest may increase metastasis, possibly through miR-3666-regulated levels.