High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

• DOI: 10.1007/s13277-015-4141-4
• Publication Date: 2015-10-12T20:25:45Z
• Authors: Baoying Yuan; Changshun Wu; Xingwen Wang; Dan Wang; Huiling Liu; Ling Guo; Xiang-An Li; Junqing Han; Hong Feng
• Keywords: Adult; Receptor, ErbB-2; Breast Neoplasms; Kaplan-Meier Estimate; Middle Aged; Scavenger Receptors, Class B; Prognosis; Immunohistochemistry; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Receptors, Estrogen; Tissue Array Analysis; Lymphatic Metastasis; Multivariate Analysis; Biomarkers, Tumor; Humans; Female; Receptors, Progesterone; Aged; Follow-Up Studies; Neoplasm Staging; Proportional Hazards Models

Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan-Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.