Do circulating long non-coding RNAs (lncRNAs) (LincRNA-p21, GAS 5, HOTAIR) predict the treatment response in patients with head and neck cancer treated with chemoradiotherapy?

• DOI: 10.1007/s13277-015-4189-1
• Publication Date: 2015-10-19T07:46:59Z
• Authors: Merdan Fayda; Mustafa Isin; Makbule Tambas; Murat Guveli; Rasim Meral; Musa Altun; Dilek Sahin; Gozde Ozkan; Yasemin Sanli; Husniye Isin; Emre Ozgur; Ugur Gezer
• Keywords: GAS5; Chemoradiotherapy; HOTAIR

Long non-coding RNAs (lncRNAs) have been shown to be aberrantly expressed in head and neck cancer (HNC). The aim of the present study was evaluate plasma levels three lncRNA molecules (lincRNA-p21, GAS5, HOTAIR) treatment response HNC patients treated with radical chemoradiotherapy (CRT). Forty-one were enrolled study. Most had nasopharyngeal carcinoma (n = 27, 65.9 %) locally advanced disease. Blood drawn at baseline evaluation 4.5 months after therapy. lncRNAs measured by semiquantitative PCR. Treatment evaluated according clinical examination, RECIST PERCIST criteria based on magnetic resonance imaging (MRI), positron emission tomography computed (PET/CT) findings. Complete (CR) rates 73.2, 36.6, 50 % for investigation, PET/CT-, or MRI-based evaluation, respectively. Predictive value investigated CR vs. those partial (PR)/progressive disease (PD). We found that post-treatment GAS5 PR/PD significantly higher compared investigation (p 0.01). Receiver operator characteristic (ROC) analysis showed a cutoff 0.3 sensitivity specificity tumor 82 77 %, Interestingly, pretreatment increased upon 0.042). In contrast lincRNA-p21 HOTAIR not informative response. Our results suggest circulating could biomarker predicting patients.