Upregulation of centrosomal protein 55 is associated with unfavorable prognosis and tumor invasion in epithelial ovarian carcinoma

• DOI: 10.1007/s13277-015-4419-6
• Publication Date: 2015-11-28T14:45:38Z
• Authors: Weijing Zhang; Chunhao Niu; Weiling He; Teng Hou; Xiaoying Sun; Liqun Xu; Yanna Zhang
• Keywords: Clinical Significance

Centrosomal protein 55 (CEP55) is a cell cycle regulator implicated in development of certain cancers. However, characteristics CEP55 expression and its clinical/prognostic significance are unclear human epithelial ovarian carcinoma (EOC). Therefore, we investigated the clinicopathological patients with EOC role regulating invasion metastasis lines. mRNA levels were detected by quantitative real-time PCR (qRT-PCR), Western blotting, immunohistochemistry (IHC). Potential associations scores clinical parameters patient survival evaluated. function was further using RNA interference, wound healing assay, transwell immunofluorescence analysis, qRT-PCR, blotting. significantly upregulated cancer lines lesions compared normal cells adjacent noncancerous tissues. In 213 samples, positively correlated stage (P < 0.001), lymph node intraperitoneal tumor recurrence differentiation grade residual size ascites see = 0.020), serum CA153 level 0.001). Moreover, aberrant showed tendencies to receive neoadjuvant chemotherapy 0.001) cytoreductive surgery 0.020). By contrast, no significant correlation between age, histological type, or CA125, CA199, CA724, NSE, CEA, β-HCG levels. Patients high had shorter overall disease-free those low expression. Multivariate analysis as an independent prognostic indicator for patients. Additionally, downregulation remarkably inhibited cellular motility invasion. Aberrant may predict unfavorable outcomes play important cells. Thus, serve marker therapeutic target EOC.