miR-488 acts as a tumor suppressor gene in gastric cancer

• DOI: 10.1007/s13277-015-4645-y
• Publication Date: 2016-01-06T21:14:12Z
• Authors: Yan Zhao; Guifang Lu; Xiquan Ke; Xinlan Lu; Xin Wang; Hongxia Li; Mudan Ren; Shuixiang He
• Keywords: PAX6; Ectopic expression

MicroRNAs (miRNAs) are small, non-coding RNAs that modulate development, cell proliferation, and apoptosis. The deregulated expression of microRNAs is found in carcinogenesis including gastric cancer (GC). In this study, we showed the levels miR-488 were downregulated GC tissues compared to non-tumor tissues. addition, was also lower lines contrast with epithelial line (GES). level negatively correlated TNM stage patients, tumors advanced stage. ectopic suppressed cycle, colony information, migration. PAX6 identified as a direct target gene HGC-27. Moreover, upregulated stage, higher Furthermore, there an inverse correlation between Therefore, these studies demonstrated might act tumor suppressor miRNA development GC.