Predictable factors for lymph node metastasis in early gastric cancer analysis of clinicopathologic factors and biological markers

• DOI: 10.1007/s13277-015-4721-3
• Publication Date: 2016-01-05T12:55:21Z
• Authors: Yi-Wei Wang; Mei-Ling Zhu; Rui-Fen Wang; Wen-Ji Xue; Xue-Ru Zhu; Li-Feng Wang; Lei-Zhen Zheng
• Keywords: Adult; Aged, 80 and over; Male; Adenocarcinoma; Middle Aged; Prognosis; 3. Good health; Immunoenzyme Techniques; 03 medical and health sciences; 0302 clinical medicine; Meta-Analysis as Topic; Gastrectomy; Stomach Neoplasms; Lymphatic Metastasis; Biomarkers, Tumor; Humans; Female; Neoplasm Invasiveness; Early Detection of Cancer; Aged; Follow-Up Studies; Neoplasm Staging; Retrospective Studies

Predicting lymph node metastasis (LNM) accurately is very important to decide treatment strategies preoperatively. The aim of this study was explore risk factors that predict the presence LNM in early gastric cancer (EGC). A total 230 patients with EGC who underwent curative gastrectomy adenectomy at Xinhua Hospital from January 2006 July 2014 were retrospectively reviewed. We studied relationship between clinicopathological factors, biological markers (p53, ki67, nm23, vascular endothelial growth factor (VEGF), epidermal receptor (EGFR), E-cadherin (E-cad), beta-catenin (b-catenin), glutathione S-transferase (GST), and topoisomerase II (Topo II)), by chi-square test logistic regression analysis. Meta-analyses further conducted review effects proteins (P53, E-cad, b-catenin) on ECG patients. detected 42 (18.3 %) Incidences distinct different tumor size (p = 0.044), depth submucosal invasion < 0.0001), P53 overexpression 0.004). Multivariate analysis indentified large (≥20 mm, odds ratio (OR) 2.168, p 0.041), submucosa (OR 4.000, 0.0005), 3.010, 0.022) independent meta-analysis revealed a significantly statistical association P53, b-catenin an increased OR 1.81, 0.017; 2.53, 0.0003; b-catenin, 0.53, 0.01). Tumor mm), (submucosa), may be helpful predictors Furthermore, results ki67 overexpression, abnormal expression associated EGC. need validation single studies.