Association of single-nucleotide polymorphisms of high-mobility group box 1 with susceptibility and clinicopathological characteristics of uterine cervical neoplasia in Taiwanese women

• DOI: 10.1007/s13277-016-5408-0
• Publication Date: 2016-10-04T12:27:15Z
• Authors: Hsin-Hung Wu; Yu-Fan Liu; Shun-Fa Yang; Wea-Lung Lin; Shiuan-Chih Chen; Chih-Ping Han; Hsiang-Ling Wang; Long-Yau Lin; Po-Hui Wang
• Keywords: SNP

To date, no study associated the genetic polymorphisms of high-mobility group box 1 protein (HMGB1) with development uterine cervical cancer. We therefore conducted this to investigate associations HMGB1 single-nucleotide (SNPs) carcinogenesis and clinicopathological characteristics cancer patients. Five hundred two women, including 112 invasive cancer, 85 precancerous lesions cervix, 305 normal controls, were consecutively enrolled into study. Analysis SNPs was done by real-time polymerase chain reaction genotyping. Our results found that risk susceptibility 1.85 (95 % CI 1.12–3.04; p = 0.016) in women TC 1.99 1.24–3.23; 0.005) TC/CC after adjusting for age, using TT as a comparison reference SNP rs1412125. In rs2249825, increased also seen CG [adjusted odds ratio (AOR) 2.04, 95 1.22–3.40; 0.006] or CG/GG (AOR 2.02, 1.22–3.32; 0.006) CC reference. An additional integrated silico analysis confirmed rs2249825 creates binding site v-Myb, which may affect expression. conclusion, Taiwanese rs1412125 well susceptible