Noninvasive Neuroprosthesis Promotes Cardiovascular Recovery After Spinal Cord Injury

• DOI: 10.1007/s13311-021-01034-5
• Publication Date: 2021-03-31T17:03:02Z
• Authors: Rahul Sachdeva; Tom E. Nightingale; Kiran Pawar; Tamila Kalimullina; Adam Mesa; Arshdeep Marwaha; Alison M.M. Williams; Tania Lam; Andrei V. Krassio...
• Keywords: Autonomic dysreflexia; Tetraplegia

Spinal cord injury (SCI) leads to severe impairment in cardiovascular control, commonly manifested as a rapid, uncontrolled rise blood pressure triggered by peripheral stimuli-a condition called autonomic dysreflexia. The objective was demonstrate the translational potential of noninvasive transcutaneous stimulation (TCS) mitigating dysreflexia following SCI, using pre-clinical evidence and clinical case report. In rats with we show that TCS not only prevents instigation dysreflexia, but also mitigates its severity when delivered during an already-triggered episode. Furthermore, multisession therapy for 6 weeks post-SCI, significantly reduced tested absence concurrent TCS. This treatment effect persisted at least 1 week after end therapy. More importantly, applicability individual cervical, motor-complete, chronic SCI. We anticipate will offer significant therapeutic advantages, such obviating need surgery resulting risk medical expenses. this study provides framework testing improving recovery other functions lower urinary tract, bowel, sexual dysfunction