The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions

• DOI: 10.1007/s13318-024-00909-0
• Publication Date: 2024-08-06T11:02:56Z
• Authors: Prajakta Harish P...; Mrunal Desai; Sumit Birangal; Gautham Shenoy Gu...; Mahadev Rao; Anandkumar Yadav; Vishwanath Kurawa...; Avinash Chaudhari; Tarun Sharma; Jakir Pinjari; Jagadish Puralae ...
• Keywords: Palbociclib; Concomitant

Numerous clinical concerns have been expressed regarding the potential worsening of cyclin-dependent kinase 4/6 inhibitor effects in breast cancer patients because co-administration proton pump inhibitors. Hence, this study evaluated inhibitors on pharmacokinetics palbociclib and ribociclib terms cytochrome P450 (CYP) 3A4 P-glycoprotein involvement.