Development of a novel nanoemulgel formulation containing cumin essential oil as skin permeation enhancer

• DOI: 10.1007/s13346-021-01025-1
• Publication Date: 2021-07-17T21:02:56Z
• Authors: Katayoun Morteza-...; Majid Saeedi; Jafar Akbari; Mohammad Eghbali; Amirhossein Babaei; Seyyed Mohammad H...; Ali Nokhodchi
• Keywords: Zeta potential; Dispersity; Diclofenac Sodium

Essential oils have been proposed as promising non-toxic transdermal permeation enhancers. Their use is limited because of their low water solubility. The nanotechnology-based strategies one the ways to overcome this limitation. This study aimed explore enhancing capability cumin essential oil in nanoemulgel systems containing diclofenac sodium. Cumin nanoemulsion was produced by high-pressure homogenization technique. formulation optimized changing HLB values a range 9.65-16.7 using different surfactant mixtures, namely, Tween 20, 80, and Span 80. Preparations were characterized polydispersity index, droplet size, zeta potential. Nanoemulsion with concentrations 2 4% incorporated into 0.75% Carbopol gel matrix make formulation, its effect performed through Franz diffusion cells. Antinociceptive activities formulations measured thermal (tail-flick) chemical (formalin) models nociception mice. Characterization exhibited that at value 9.65, smallest particle size (82.20 ± 5.82 nm) formed. By increasing percentage from 1 2%, increased 28.39 1.23 34.75 1.07 µg/cm2 24 h. simple (21.18 2.51 µg/cm2) marketed product (22.97 1.92 lower than oil. Nanoemulgel showed stronger antinociceptive effects formalin tail-flick tests formulation. In conclusion, proved could be considered skin enhancer enhance therapeutic drugs.