High Acute Myeloid Leukemia derived VEGFA levels are associated with a specific vascular morphology in the leukemic bone marrow

• DOI: 10.1007/s13402-011-0017-9
• Publication Date: 2011-04-05T16:39:18Z
• Authors: Alida C. Weidenaar; Arja ter Elst; Gineke Koopmans-K...; Stefano Rosati; Wilfred F. A. den...; Tiny Meeuwsen-de ...; Willem A. Kamps; Edo Vellenga; Eveline S. J. M. ...
• Keywords: CD31

Acute Myeloid Leukemia (AML) bone marrow biopsies at diagnosis display enhanced angiogenesis and increased VEGFA expression. In a xenograft mouse model it was described that availability of free versus bound is related to different vascular morphology. this study we investigate the relationship between morphology within AML derived levels.Vessel count surface area (Chalkley count) were calculated in (n = 32), remission 8) Normal Bone Marrow 32) using immunohistochemical staining for FVIII, CD31, CTIV, SMA VEGFA. protein levels measured.High vessel associated with an immature status. Combining Chalkley patterns quantified biopsies. Three subgroups could be distinguished. The subgroup (37.5% samples) exhibiting high vessels predominantly large lumen (normal secreted levels.Different vasculature are seen biopsies, defined by combining number size vessel. These patterns, combined levels, might value success VEGF/VEGFR-signaling interference approaches.