Reductions in C‐reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training

• DOI: 10.1007/s13539-014-0134-1
• Publication Date: 2014-02-11T16:21:27Z
• Authors: Yorgi Mavros; Shelley Kay; Kylie A. Simpson; Michael K. Baker; Yi Wang; Ren R. Zhao; Jacinda Meiklejohn; Mike Climstein; Anthony J. O'Sull...; Nathan de Vos; Bernhard T. Baune; Steven N. Blair; David Simar; Kieron Rooney; Nalin A. Singh; Maria A. Fiataron...
• Keywords: Bioelectrical Impedance Analysis

Reductions in skeletal muscle mass and increased adiposity are key elements the aging process pathophysiology of several chronic diseases. Systemic low grade inflammation associated with obesity has been shown to accelerate age-related decline muscle. The aim this investigation was determine effects 12 months progressive resistance training (PRT) on systemic inflammation, whether reductions were changes body composition. We hypothesized that following PRT older adults type 2 diabetes would be increases mass.Participants (n = 103) randomized receive either or sham-exercise, 3 days a week for months. C-reactive protein (CRP) used assess inflammation. Skeletal total fat determined using bioelectrical impedance.Twelve tended reduce CRP compared sham exercise (β -0.25, p 0.087). Using linear mixed-effects models, relationships between composition adaptations significantly stronger (p 0.04) 0.07) when sham-exercise. univariate regression stratified by group allocation, 0.01) 0.02) group, but not sham-exercise 0.87 0.32, respectively).We have first time mass. Furthermore, adiposity, only PRT. Lifestyle interventions aimed at reducing should therefore incorporate anabolic such as optimize anti-inflammatory benefits favorable adaptations.