An Effective and Safe Laser Treatment Strategy of Fractional Carbon Dioxide Laser for Chinese Populations with Periorbital Wrinkles: A Randomized Split-Face Trial

• DOI: 10.1007/s13555-025-01404-3
• Publication Date: 2025-04-12T10:16:49Z
• Authors: Xianglei Wu; Qingqing Cen; Jian Jin; Wei Gao; Ying Shang; Linting Huang; Xiaoxi Lin
• Keywords: Carbon dioxide laser

Ablative carbon dioxide fractional laser (CO2 AFL) can alleviate static wrinkles; however, its use in East Asian populations predispose them to postinflammatory hyperpigmentation (PIH). We aimed explore the optimum energy and coverage parameters of CO2 AFL for treating periorbital wrinkles a Chinese population minimize PIH incidence. In total, 30 patients with were recruited. The intervention side (1% hydroquinone cream every night on one area each patient 1 month before from 8th day after treatment) group (group A: 15‒20 mJ, 5%; B: 10‒12.5 15%; C: 12.5‒15 10%) determined randomly. underwent two sessions at 3-month intervals. Follow-ups conducted until 6 months last treatment. Overall, 20 participants (48.1 ± 13.1 years) completed all follow-ups without any serious complications. application significantly reduced (p = 0.02). Both investigators' patients' visual evaluations demonstrated consistent efficacy rate 68.2% differences between groups. Fitzpatrick wrinkle score decreased compared pre-treatment < 0.01); significant reduction only B 3 0.016) 0.001) post-treatment was observed. Groups C reductions superficial deep pigmentation 0.01). effectively population. Low combined high-density most efficacious. Clinical Trial Registration no. ChiCTR2400087320 (date trial registration: 25 July 2024).