Fathering a child after childhood cancer treatments

• DOI: 10.1007/s13629-022-00350-5
• Publication Date: 2022-02-07T15:02:31Z
• Authors: Joana B. Serrano; Andreas Meißner; Ans M. M. van Pelt; Callista L. Mulder
• Keywords: Childhood Cancer

Abstract Among many deleterious ramifications of oncological treatments, there is permanent male infertility due to the damage spermatogonial stem cells (SSC) in testes after chemotherapy or irradiation. For those patients that cannot produce sperm before cancer treatment, because prepubertal age, are no clinical options available father a child. To preserve fertility childhood patients, freezing testis biopsy already offered while treatment using this still under development, including cell transplantation (SSCT). SSCT requires isolation and vitro propagation from cryopreserved biopsy, followed by autologous back adult survivor. Given implications potential therapy recipients, their partners, future offspring, we here aim thoroughly appraise state-of-the-art focussing on safety for both patient his children.