Discovery of a parallel family of euglenatide analogs in Euglena gracilis

Euglena gracilis Bioorganic chemistry Euglena Cancer cell lines
DOI: 10.1007/s13659-024-00490-8 Publication Date: 2025-01-06T06:55:03Z
ABSTRACT
Abstract The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis . These compounds have antiproliferative activity against fungal pathogens and mammalian cancer cell lines. Analysis E. extracts revealed that produce not only euglenatides, but also corresponding analogs same molecular weights as lacking characteristic triene chromophore. In comparison to these is greatly reduced in cytotoxicity assay, indicating critical biological euglenatides. Graphical abstract
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