Discovery of a parallel family of euglenatide analogs in Euglena gracilis

• DOI: 10.1007/s13659-024-00490-8
• Publication Date: 2025-01-06T06:55:03Z
• Authors: Ahmed H. Elbanna; Xinhui Kou; Dilip V. Prajapati; Surasree Rakshit; Rebecca A. Butcher
• Keywords: Euglena gracilis; Bioorganic chemistry; Euglena; Cancer cell lines

Abstract The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis . These compounds have antiproliferative activity against fungal pathogens and mammalian cancer cell lines. Analysis E. extracts revealed that produce not only euglenatides, but also corresponding analogs same molecular weights as lacking characteristic triene chromophore. In comparison to these is greatly reduced in cytotoxicity assay, indicating critical biological euglenatides. Graphical abstract