Concise syntheses of natural diarylheptanoids containing a 1,4-pentadiene unit

• DOI: 10.1007/s13659-025-00517-8
• Publication Date: 2025-05-13T06:33:04Z
• Authors: Guang Tao; Xin-Yue Hu; Hong-Xing Liu; Xing-Ren Li; Li-Dong Shao; Gang Xu
• Keywords: Diarylheptanoids; Moiety

Abstract Two concise and efficient synthetic routes were developed for the synthesis of three 1,7-diarylheptanoids ( 1 – 3 ) containing a 1,4-pentadiene unit, which originally isolated from Ottelia acuminata var. . The first approach focused on construction linear diarylheptanoids featuring (1 E ,4 )-pentadiene moiety, via Suzuki coupling reaction. second strategy enabled sixteen-membered macrocyclic ether 2 with Z unit. challenging macrocyclization was successfully accomplished through an Ullmann coupling. Notably, formation -olefin within framework promoted by inherent ring strain diarylether-type heptane system, preferentially stabilizes this particular configuration. Graphical