Colorectal anastomotic leakage after conversion surgery for advanced endometrial cancer treated with lenvatinib plus pembrolizumab: a case report

• DOI: 10.1007/s13691-024-00739-6
• Publication Date: 2024-12-10T13:42:33Z
• Authors: Akitoshi Yamamura; Junzo Hamanishi; Koji Yamanoi; Masumi Sunada; Mana Taki; Rin Mizuno; Yukiko Okada; Ryusuke Murakami; Yuki Aisu; Hisatsugu Maekawa; Ken Yamaguchi; Masaki Mandai
• Keywords: Colorectal Surgery

Abstract The combination therapy of lenvatinib plus pembrolizumab (LP) is increasingly recognized as an important second-line regimen for advanced or recurrent endometrial cancer (EC). However, the safety and efficacy conversion surgery with low anterior rectal resection unresectable EC following LP unknown. A 37-year-old woman was referred pleural fluid, peritoneal dissemination, ascites. After failure first-line platinum-based chemotherapy, she administered treatment. 10 treatment cycles, uterine tumors significantly reduced in size, except left ovarian metastatic tumor which became slightly larger. Cytoreductive surgery, including rectum colorectal anastomosis, achieved complete resection. on postoperative day 11, patient experienced anastomotic leakage around anastomosis site, necessitating a double-barreled colostomy percutaneous drainage. She discharged 15 days after second resumed 44 surgery. We report case conducted cancer. Our findings indicate that if bowel required, longer preoperative withdrawal period may be necessary to prevent leakage.