Glasgow prognostic score for assessing the efficacy of whole-brain radiation therapy in cases of recursive partitioning analysis class 2 and class 3 multiple brain metastases: a retrospective study

• DOI: 10.1007/s13760-023-02384-x
• Publication Date: 2023-09-25T11:02:22Z
• Authors: Yojiro Ishikawa; Rei Umezawa; Takaya Yamamoto; Noriyoshi Takahashi; Kazuya Takeda; Yu Suzuki; Keita Kishida; So Omata; Satoshi Teramura; Kengo Ito; Takayuki Yamada; Keiichi Jingu
• Keywords: Recursive partitioning; Univariate analysis; Karnofsky Performance Status

Abstract Purpose Whole-brain radiotherapy (WBRT) may not be beneficial for patients with brain metastases (BMs). The Glasgow Prognostic Score (GPS) is a suggested prognostic factor malignancies. However, GPS has never been assessed in BMs who have undergone WBRT. purpose of this study was to determine whether can used identify subgroups poor prognosis, such as recursive partitioning analysis (RPA) Class 2 and 3, will receive clinical benefits from Materials methods A total 180 Japanese were treated WBRT between May 2008 October 2015. We examined GPS, age, Karnofsky Performance Status (KPS), RPA, graded assessment (GPA), number lesions, tumor size, history surgery, presence symptoms, radiation doses. Results overall median survival time (MST) 6.1 months. seventeen (9.4%) alive more than years after In univariate analysis, KPS ≤ 70 (p = 0.0066), GPA class 0–2 0.0008), > 3 0.012), 4 0.02), received ≥ Gy per fraction 0.0068), 1 0.0003), 0.0009) found significantly decrease the MST. Patients had surgery before 0.036) longer survival. On multivariate 0.008) Conclusion Our results suggest that indicates prognosis undergoing intermediate BMs.