Green synthesis of polyhydroquinolines via MCR using Fe3O4/SiO2-OSO3H nanostructure catalyst and prediction of their pharmacological and biological activities by PASS

• DOI: 10.1007/s40097-017-0240-7
• Publication Date: 2017-09-20T08:32:51Z
• Authors: Ali Maleki; Ali R. Akbarzade; Ajmal R. Bhat
• Keywords: Ethyl acetoacetate; Dimedone; Nanochemistry

In this work, a library of diverse chemically and medicinally important heterocyclic polyhydroquinoline derivatives was efficiently prepared via one-pot multicomponent reaction starting from various raw materials including aromatic aldehydes, dimedone or 1,3-cyclohexandione, ethyl acetoacetate methyl ammonium acetate in the presence Fe3O4/SiO2-OSO3H as sulfonated silica-based magnetic nanocatalyst high yields. Main advantages present practical approach are ready availability materials, non-toxicity, inexpensiveness, ease workup procedure, diversity orientation synthesis an eco-friendly nature reaction. The characterized by Fourier transform infrared (FT-IR) spectra, scanning electron microscopy (SEM) images energy-dispersive X-ray spectroscopy (EDX) spectra. simply recovered using external magnet reused several times. Then, pharmacological biological activities products were theoretically examined prediction activity spectra for substances (PASS) program.