Cardiovascular Outcomes of Early LDL-C Goal Achievement in Patients with Very-High-Risk ASCVD

• DOI: 10.1007/s40119-025-00397-6
• Publication Date: 2025-02-23T20:06:06Z
• Authors: Ah-Ram Kim; Ji Ye Han; Minkyoung Kim; Hojoon Lee; Yeon-Hee Baek; Imjin Ahn; Hee Jun Kang; Ji Seon Oh; Ju Hyeon Kim; Osung Kwon; Tae Joon Jun; Sun U. Kwon; Young-Hak Kim
• Keywords: Atherosclerotic cardiovascular disease

Clinical trial evidence supports early low-density lipoprotein cholesterol (LDL-C) goal achievement in patients with atherosclerotic cardiovascular disease (ASCVD), but real-world Asia is lacking. We investigated the effects of LDL-C on recurrent major events (MACEs) among very-high-risk ASCVD South Korea. included adult hospitalized (acute coronary syndrome [ACS], stable angina, ischemic stroke, transient attack, peripheral arterial disease, or asymptomatic artery disease) at a Korean tertiary hospital from 2000 to 2020. Patients were categorized into non-early target groups based measured 4–12 weeks post-discharge (< 55 vs. ≥ mg/dl). The primary outcome was MACEs, including myocardial infarction, all-cause mortality, hospitalization for unstable and revascularization. secondary health resource use (frequency/length stay [LOS]). During follow-up (mean: 5 years), group (n = 5702) had lower risk MACEs compared 11,232; adjusted hazard ratio [95% CI]: 0.89 [0.82–0.96]). effect most pronounced ACS (0.73 [0.63–0.85]), particularly within 6 months (0.61 [0.44–0.87]). 19% frequency 31% shorter LOS cardiovascular-related hospitalizations than group. Early associated Korea, especially ACS. These findings underscore importance management improving outcomes.