Risk of Adverse Outcomes for Older People with Dementia Prescribed Antipsychotic Medication: A Population Based e-Cohort Study

• DOI: 10.1007/s40120-016-0060-6
• Publication Date: 2017-01-04T00:40:49Z
• Authors: Michael Dennis; Laura Shine; Ann John; Amanda Marchant; Joanna McGregor; Ronan A. Lyons; Sinead Brophy
• Keywords: Stroke

Over recent years there has been growing evidence of increased risk mortality associated with antipsychotic use in older people dementia. Although this concern combined limited efficacy informed guidelines restricting prescription population, the antipsycotics remains common. Many published studies only report short-term outcomes, are restricted to examining and stroke or have other limitations. The aim study was assess adverse outcomes antipsychotics living dementia Wales (UK).This a retrospective population-based cohort using Welsh Secure Anonymised Information Linkage databank. prior event rate ratio (PERR) used estimate influence exposure medication on acute cardiac events, venous thromboembolism, hip fracture, adjusted Cox proportional hazard models were compare all-cause mortality.A total 10,339 aged ≥65 identified newly diagnosed After excluding those who did not meet inclusion criteria, 9674 remained main whom 3735 exposed medication. An thromboembolic episode [PERR 1.95, 95% confidence interval (CI) 1.83-2.0], (PERR 1.41, CI 1.4-1.46) fracture 1.62, 1.59-1.65) use. However, no long-term (adjusted 1.06, 0.99-1.13).The increase medical events supports population.