Plasma lncRNA LIPCAR Expression Levels Associated with Neurological Impairment and Stroke Subtypes in Patients with Acute Cerebral Infarction: A Prospective Observational Study with a Control Group

• DOI: 10.1007/s40120-023-00482-9
• Publication Date: 2023-05-17T10:02:22Z
• Authors: Zhong-zhong Liu; Wen-juan Lin; Yue Feng; Cong-li Huang; Yin-fang Yan; Wei-yan Guo; Huan Zhang; Zhen Lei; Qing-li Lu; Pei Liu; Xue-mei Lin; Song-di Wu
• Keywords: Stroke

This prospective observational study with a control group aimed to compare the plasma levels of long non-coding RNA (lncRNA) LIPCAR between patients acute cerebral infarction (ACI) and healthy controls, assess prognostic abilities for adverse outcomes ACI at 1-year follow-up. Eighty ACI, whom 40 had large artery atherosclerosis (LAA) cardioembolism (CE) who were hospitalized Xi'an No. 1 Hospital from July 2019 June 2020, selected as case group. Age- sex-matched non-stroke same hospital throughout time period chosen Real-time quantitative reverse transcription polymerase chain reaction was used measure lncRNA LIPCAR. The correlations expression among LAA, CE, groups assessed using Spearman's correlation analysis. Curve fitting multivariate logistic regression analyze its subtypes. in noticeably higher than that (2.42 ± 1.49 vs. 1.00 0.47, p < 0.001). Patients CE considerably those LAA. National Institute Health Stroke Scale score modified Rankin scale on admission significantly positively correlated Furthermore, stronger coefficients 0.69 0.64, respectively. revealed non-linear levels, recurrent stroke, all-cause mortalities, poor prognoses, cut-off value 2.2. level may play potential role identification neurological impairment subtype ACI. Increased risk be associated high expression.