The Mediating Effect of Intracranial Hemorrhage Status on the Relationship between the INR and Mortality in Patients with Ischemic Stroke

• DOI: 10.1007/s40120-025-00715-z
• Publication Date: 2025-04-09T15:31:21Z
• Authors: Yapeng Guo; Lingshan Wu; Zhenxuan Tian; Xu Xu; Jinfu Ma; Changwei Guo; Linyu Li; Jie Yang; Wenjie Zi; Jiacheng Huang; Xianjun Huang
• Keywords: Stroke

The international normalized ratio (INR) is a biomarker of coagulopathy. objective this study was to assess the relationship between INR and clinical outcomes in patients with large vessel occlusion (LVO) stroke who received endovascular therapy. RESCUE BT trial multicenter, randomized, double-blind, placebo-controlled involving 948 from 55 centers across China. We extracted data related database, outcome measures comprising intracranial hemorrhage (ICH) 90-day mortality. Logistic regression analysis conducted examine associations entire patient cohort different stratified subgroups. A total 885 met criteria, 672 exhibiting normal 213 showing an elevated INR. Multivariable indicated that linked increased risk ICH (OR 1.65, 95% confidence interval CI 1.17-2.33, P =0.005) mortality 1.78, 1.17-2.70, =0.007). Mediation association partially mediated by status, mediation effect contributing 11.4% overall relationship. Subgroup analyses revealed no significant differences subgroups (P for interaction > 0.05). In receiving tirofiban, more strongly associated rate 7.75, 1.42-42.33, =0.018). Our findings underscore critical importance monitoring LVO undergoing treatment (EVT). through status. use tirofiban strengthened higher rate. These insights offer valuable guidance optimizing outcomes. URL: http://www.chictr.org.cn ; ChiCTR-INR-17014167.