Fatal Infections Among Cancer Patients: A Population-Based Study in the United States

• DOI: 10.1007/s40121-021-00433-7
• Publication Date: 2021-03-24T11:03:56Z
• Authors: Yongqiang Zheng; Ying Chen; Kaixu Yu; Yun Yang; Xindi Wang; Xue Yang; Jiaxin Qian; Ze-Xian Liu; Bian Wu
• Keywords: Standardized mortality ratio; Cumulative incidence

Cancer patients are prone to infections, but the mortality of fatal infections remains unclear. Understanding patterns in with cancer is imperative. In this study, we report characteristics, incidence, and predictive risk factors among a population-based cohort. A total 8,471,051 diagnosed between 1975 2016 were retrospectively identified from Surveillance, Epidemiology, End Results (SEER) program. The primary outcome was dying infections. Mortality rates standardized ratios (SMRs) adjusted for age, sex, race, calendar year calculated characterize relative risks compare general population. Furthermore, cumulative Cox regression models applied identify patients, rate 260.1/100,000 person-years, nearly three times that population [SMR, 2.92; 95% (confidence interval) CI 2.91–2.94]. Notably, decreasing trend observed recent decades. SMRs highest Kaposi sarcoma (SMR, 162.2; 159.4–165.1), liver 30.9; 30.0–31.8), acute lymphocytic leukemia 19.1; 17.0–21.4), myeloid 13.3; 12.4–14.3). Patients aged 20 39 years old exhibited higher first few after diagnosis, whereas those > 80 rapidly increasing became approximately 3 post-cancer diagnosis. Predictive age 20–39 or years, male black before 2000, unmarried status, advanced stage, not receiving surgery radiotherapy, chemotherapy. at high infectious diseases. Certain groups including as well chemotherapy, should be sensitized