Management of Neovascular Age-Related Macular Degeneration Treatment in France from 2008–2018: The Nationwide LANDSCAPE Study

• DOI: 10.1007/s40123-023-00772-3
• Publication Date: 2023-08-02T04:01:21Z
• Authors: Catherine P. Creu...; Mayer Srour; Florian Baudin; Corinne Dot; Sylvia Nghiem-Buffet; Jean-Francois Gir...; Cedric Collin; Anne Ponthieux; Cécile Delcourt
• Keywords: Ophthalmology; [SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs; Anti-VEGF; Real-world management; 610; [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs; RE1-994; Real-world managementNeovascular age-related macular degeneration; Système National des Données de Santé; Neovascular age-related macular degeneration; Original Research

The aim of this study was to describe the management neovascular age-related macular degeneration (nAMD) in French patients between 2008 and 2018. This a retrospective longitudinal cohort using exhaustive nationwide health records from National Health Information database. Enrollment criteria were adults aged ≥ 50 years, nAMD diagnosis, or reimbursement for treatments (anti-vascular epithelial growth factor [VEGF] injection dynamic phototherapy with verteporfin). Exclusion high myopia, diagnosis other retinal diseases, diseases (dexamethasone implant, laser). Main outcome measures consumption medical care per calendar year number years follow-up. Between 2018, we identified 342,961 who have been treated nAMD. Median duration ophthalmological follow-up exceeded 7 (90 months). median annual ophthalmology consultations decreased nine visits 1 after treatment initiation four onwards. 10.1 months all patients, 48.5% undergoing < year. Only 24.4% had maintained at 11. Patients remaining under anti-VEGF throughout 10-year period. Ranibizumab more common first-line (67.5% patients) compared aflibercept (32.4%). About 20% initiated switched least once. LANDSCAPE provides data on real-world France over Further investigation into short is required, especially terms understanding its relation visual outcomes.