The Effects of Repeated Low-Level Red-Light Therapy on the Structure and Vasculature of the Choroid and Retina in Children with Premyopia

• DOI: 10.1007/s40123-023-00875-x
• Publication Date: 2024-01-10T09:02:11Z
• Authors: Zhuzhu Liu; Ziwen Sun; Bei Du; Huaixue Gou; Biying Wang; Zeya Lin; Nuo Ren; Emmanuel Eric Pazo; Lin Liu; Ruihua Wei
• Keywords: Choroid

The purpose of this study was to explore the effects repeated low-level red-light (RLRL) therapy on structure and vasculature choroid retina in Chinese children with premyopia. This a single-center randomized clinical trial. A total 94 premyopia (− 0.50 D < spherical equivalent [SE] ≤ + 0.75 D) were randomly assigned either RLRL or control group. Follow-up visits planned at 1, 3, 6, 9, 12 months. Optical coherence biometry used measure axial length (AL) anterior segment parameters. Choroidal thickness (CT), retinal (RT), superficial vascular density (SRVD), deep (DRVD), choriocapillaris perfusion area (CCPA), choroidal vessel volume (CVV) measured by optical tomography angiography, centered foveal, parafoveal (ParaF), perifoveal (PeriF) regions. thickening observed across entire macular region different time points Relative baseline measurement, foveal CT significantly increased 1-month follow-up therapy, mean (± standard deviation [SD]) adjusted change 16.96 ± 19.87 μm. greatest magnitude changes 3-month visit (an increase 19.58 20.59 μm), slight reduction extent 6-month 15.85 23.77 μm). second 9-month 19.57 35.51 after which gradually decreased until end 12-month 11.99 32.66 We also significant ParaF PeriF areas group over In contrast, throughout (all P 0.05). Regarding parameters choroid, increases CVV primarily regions comparison, exhibited decreases area. Furthermore, notable elevations CCPA detected during 0.40 mm2), 0.25 0.42 mm2) addition, no differences between groups regarding RT months (P > Notably, achieved SE shift 73.8%, substantial decrease AL 67.9%, myopia incidence 45.1% within 1 year. Our demonstrated flow RLRL-treated eyes 12-months study. Combined its progression elongation, could be as an effective for preventing premyopes. ChiCTR2200062028.