Solvent-free 1,3-dipolar cycloaddition of azomethine imines with terminal alkynes promoted by calcium fluoride under the ball milling condition

• DOI: 10.1007/s40242-015-4480-0
• Publication Date: 2015-07-10T10:27:09Z
• Authors: Xianglong Chen; Chunman Jia; Li Cao; Dela Zhang; Shuixiang Liu; Qi Zhang
• Keywords: 01 natural sciences; 0104 chemical sciences

A convenient and efficient procedure for the synthesis of N,N-bicyclic pyrazolidinone derivatives has been developed via the reaction of azomethine imines with terminal alkynes under the ball milling condition without solvent, which was promoted by calcium fluoride with a catalyst of copper(I) salt. The cyclization reactions exhibited moderate to high yields.