Performance of Eight Infliximab Population Pharmacokinetic Models in a Cohort of Dutch Children with Inflammatory Bowel Disease

• DOI: 10.1007/s40262-024-01354-7
• Publication Date: 2024-03-15T13:01:41Z
• Authors: Nanja C. Bevers; Ron J. Keizer; Dennis R. Wong; Arta Aliu; Marieke J. Pierik; Luc J. J. Derijks; Patrick F. van Rh...
• Keywords: Therapeutic Drug Monitoring; Trough Concentration; Trough level

Efficacy of infliximab in children with inflammatory bowel disease can be enhanced when serum concentrations are measured and further dosing is adjusted to achieve maintain a target concentration. Use population pharmacokinetic model may help predict an individual's dose requirement. The aim this study was evaluate the predictive performance available models independent cohort Dutch disease.