Association Between Use of Multiple Psychoactive Medicines and Hospitalization for Falls: Retrospective Analysis of a Large Healthcare Claim Database

• DOI: 10.1007/s40264-014-0179-2
• Publication Date: 2014-05-28T14:53:53Z
• Authors: Nicole L. Pratt; Emmae N. Ramsay; Lisa M. Kalisch E...; Tuan A. Nguyen; John D. Barratt; Elizabeth E. Roug...
• Keywords: Psychoactive drug

Little is known about the impact of taking multiple psychoactive medicines on risk hospitalization for falls.To identify association between medicine use and falls.A retrospective cohort study was conducted July 2011 June 2012 in Australian veteran population who had been dispensed at least one within previous year. Psychoactive with sedative properties included antipsychotics, anxiolytics, hypnotics, antidepressants, opioids, anti-epileptics, anti-Parkinson migraine. The associations falls number used or doses were analysed comparison that occurred when no used.The adjusted results showed a significantly increased patients more receiving 0.1-0.9 defined daily dose (DDD) per day. incident rate ratios (IRRs) 1.22 (95% confidence interval [CI] 1.08-1.38) those medicine, 1.70 CI 1.45-1.99) two, 1.96 1.58-2.43) three four, 3.15 1.90-5.23) five more. A similar result observed data by dose, highest being found DDD day (adjusted IRR 4.26, 95% 2.75-6.58).Increased numbers are associated an older adults. Strategies to reduce burden likely translate into significant health benefits.