Phenotype Algorithms for the Identification and Characterization of Vaccine-Induced Thrombotic Thrombocytopenia in Real World Data: A Multinational Network Cohort Study

• DOI: 10.1007/s40264-022-01187-y
• Publication Date: 2022-06-02T10:04:56Z
• Authors: Azza Shoaibi; Gowtham A. Rao; Erica A. Voss; Anna Ostropolets; Miguel Angel Mayer; Juan Manuel Ramír...; Filip Maljković; Biljana Carević; Scott Horban; Daniel R. Morales; Talita Duarte-Salles; Clement Fraboulet; Tanguy Le Carrour; Spiros Denaxas; Vaclav Papez; Luis H. John; Peter R. Rijneek; Evan Minty; Thamir M. Alshammari; Rupa Makadia; Clair Blacketer; Frank DeFalco; Anthony G. Sena; Marc A. Suchard; Daniel Prieto-Alh...; Patrick B. Ryan
• Keywords: 0301 basic medicine; COVID-19 Vaccines; /dk/atira/pure/subjectarea/asjc/3000/3004; /dk/atira/pure/subjectarea/asjc/3000/3005; 610; COVID-19; name=Toxicology; Thrombosis; name=Pharmacology; Vacunes -- Efectes secundaris; Thrombocytopenia; 3. Good health; Fenotip; Cohort Studies; name=Pharmacology (medical); 03 medical and health sciences; Phenotype; SDG 3 - Good Health and Well-being; Trombocitopènia; /dk/atira/pure/subjectarea/asjc/2700/2736; Humans; Original Research Article; Algorithms; Retrospective Studies

Vaccine-induced thrombotic thrombocytopenia (VITT) has been identified as a rare but serious adverse event associated with coronavirus disease 2019 (COVID-19) vaccines. In this study, we explored the pre-pandemic co-occurrence of thrombosis (TWT) using 17 observational health data sources across world. We applied multiple TWT definitions, estimated background rate TWT, characterized patients, and makeup types among patients. conducted an international network retrospective cohort study electronic records insurance claims data, estimating rates amongst persons observed from 2017 to 2019. Following principles existing VITT clinical was defined patients diagnosis embolic or arterial venous events measurement within 7 days. Six phenotypes were considered, which varied in approach taken defining real world data. Overall incidence ranged 1.62 150.65 per 100,000 person-years. Substantial heterogeneity exists by age, sex, alternative phenotypes. likely be men older age various comorbidities. Among types, most common. Our findings suggest that identifying presents substantial challenge, implementing case definitions based on results large heterogeneous patints baseline characteristics are inconsistent cases reported date.