Australian Utility Weights for the EORTC QLU-C10D, a Multi-Attribute Utility Instrument Derived from the Cancer-Specific Quality of Life Questionnaire, EORTC QLQ-C30

• DOI: 10.1007/s40273-017-0582-5
• Publication Date: 2017-12-21T08:41:26Z
• Authors: Madeleine T. King; Rosalie Viney; A. Simon Pickard; Donna Rowen; Neil K. Aaronson; John E. Brazier; David Cella; Daniel S. J. Costa; Peter M. Fayers; Georg Kemmler; Helen McTaggart-C...; Rebecca Mercieca-...; Stuart Peacock; Deborah J. Street; Tracey A. Young; Richard Norman
• Keywords: Health Economics

The EORTC QLU-C10D is a new multi-attribute utility instrument derived from the widely used cancer-specific quality-of-life (QOL) questionnaire, QLQ-C30. contains ten dimensions (Physical, Role, Social and Emotional Functioning; Pain, Fatigue, Sleep, Appetite, Nausea, Bowel Problems), each with four levels. To be in cost-utility analysis, country-specific valuation sets are required.The aim of this study was to provide Australian weights for QLU-C10D.An online panel quota-sampled ensure population representativeness by sex age (≥ 18 years). Participants completed discrete choice experiment (DCE) consisting 16 choice-pairs. Each pair comprised two health states plus life expectancy. Data were analysed using conditional logistic regression, parameterised fit quality-adjusted life-year framework. Utility calculated as ratio QOL dimension-level coefficient on expectancy.A total 1979 members opted in, 1904 (96%) at least one choice-pair, 1846 (93%) all Dimension generally monotonic: poorer levels within dimension associated greater decrements. that impacted most were, order, Physical Functioning, Role Functioning Functioning. Oncology-relevant moderate impact Nausea Problems. Trouble Sleeping Appetite had relatively small impact. value worst state -0.096, somewhat worse than death.This provides first set QLU-C10D, which can facilitate analyses when applied data collected QLQ-C30, prospectively retrospectively.