Analysis of a mathematical model of periodically pulsed chemotherapy treatment

0301 basic medicine 0303 health sciences 03 medical and health sciences 13. Climate action 7. Clean energy 3. Good health
DOI: 10.1007/s40435-015-0204-z Publication Date: 2015-09-05T06:11:42Z
ABSTRACT
In this paper, we have considered competition models describing tumor–normal–immune cell interaction with the added effects of periodically pulsed chemotherapy. The parametric conditions needed to prevent relapse following attempts to remove the tumor or tumor metastasis are obtained. The effects of resistant tumor sub-populations are also investigated and recurrence prevention strategies are discussed. Our analytical findings are explained through numerical simulation which show the reliability of our models from the epidemiological point of view.
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