Impact of age on plasma vaspin concentration in a group of normal Chinese people

• DOI: 10.1007/s40618-016-0533-6
• Publication Date: 2016-09-07T12:03:59Z
• Authors: X. Xu; J. Wen; Y. Lu; H. Ji; J. Zhuang; Y. Su; B. Liu; H. Li; Y. Xu
• Keywords: Quartile

Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipocytokine with insulin-sensitizing effects. Accumulating data implied that vaspin represents a compensatory mechanism but it unknown how change during ageing. This study was designed to examine the correlation between plasma and age in group of normal Chinese people.A total 191 volunteers aged 19-80 years were enrolled into four groups based upon quartiles (19-35, 36-50, 51-65 66-80 years). Demographic, anthropometric, metabolic covariates, adiponectin measured. The influence on analysed using SPSS 13.0.Vaspin increased ageing, mean levels (ng/mL) 1.01 ± 2.25, 1.67 2.95, 2.05 3.46 2.40 3.06 for those quartile ages 19-35, years. When divided subgroups, increasing both sexes, insulin resistance non-insulin subjects obese lean subjects. In univariate analyses, level positively associated (r = 0.215, p 0.003), adiponectin, insulin, homoeostasis model assessment index waist-hip ratio whole population. ageing remained significant after multivariate adjustments factors such as sex, body mass index, ratio, indices glucose metabolism, white blood cell, lipid profile adiponectin. Stepwise multiple regression analysis showed contributed 7.6 % level.Vaspin independent other markers adiposity.