Correlation of Objective Endpoints and Subjective Patient-Reported Outcomes in NAFLD Treatment with Essential Phospholipids: Real-World Data Based on Pooled Analysis of Observational Studies

• DOI: 10.1007/s40801-021-00250-x
• Publication Date: 2021-05-15T17:02:36Z
• Authors: Vladimir T. Ivashkin; Marina V. Maevskaya; Elena N. Shirokova; Igor V. Maev; Alexey A. Samsonov; Evgeniy I. Sas; Liudmila K. Palgova; Kirill Starostin
• Keywords: Steatosis; Clinical endpoint

While no "gold-standard" pharmacotherapy for nonalcoholic fatty liver disease (NAFLD) is yet established, essential phospholipids (EPLs) are reported to decrease steatosis and improve laboratory parameters. This analysis evaluated adherence satisfaction with EPL treatment as patient-reported outcomes their relationship changes in ultrasound parameters among Russian patients NAFLD. Data were pooled from three observational studies—MANPOWER (2015–2016), LIDER 1 (2012–2013), 2 (2013)—in which EPLs used at least 12 weeks the of diseases measured both subjective objective endpoints. Only who had NAFLD included this analysis. The main endpoints determine therapy, between adherence/satisfaction A secondary subgroup was performed identify responded better (or worse) 24 adjunctive treatment. Overall, 3384 included. total 82.2% adherent treatment; high/very high by 15.3%/65.9% clinicians 15.9%/64.4% patients. There positive correlation patients' significant improvement (transaminases, lipid profile; p < 0.001) (steatosis, parameters, symptoms (p after EPL. Male patients, unhealthy lifestyles, those more comorbidities showed a response Patients treated therapy real-world clinical practice Russia good satisfaction. Improvements well dynamics patient symptoms, positively correlated Nonalcoholic major cause disease, have risk cancer needing transplantation. advanced usually recommended use medication. Clinical trials that comprising phosphatidylcholine improved fat accumulation (known steatosis), so guidelines several countries recommend they be added usual therapy. been associated improvements. study studies assess how related almost two-thirds (64.4%) (65.9%) very Patients' increased alongside improvements enzymes, levels, content (steatosis), fewer an lifestyle, other comorbid conditions best shows routine highlights importance these