Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy

• DOI: 10.1007/s40820-018-0227-z
• Publication Date: 2018-10-25T07:12:49Z
• Authors: Peng Xue; Ruihao Yang; Lihong Sun; Qian Li; Lei Zhang; Zhigang Xu; Yuejun Kang
• Keywords: Indocyanine Green; Prussian blue; Nanocarriers

Indocyanine green (ICG) is capable of inducing a photothermal effect and the production cytotoxic reactive oxygen species for cancer therapy. However, major challenge in applying ICG molecules antitumor therapy associated with their instability aqueous conditions rapid clearance from blood circulation, which causes insufficient bioavailability at tumor site. Herein, we conjugated Prussian blue nanoparticles enclosing Fe3O4 nanocore, was facilitated by cationic polyethyleneimine via electrostatic adsorption. The nanocarrier-loaded formed stable aggregates that enhanced cellular uptake prevented fluorescence quenching. Moreover, strong superparamagnetism core obtained nanocomposites further improved internalization drugs guided localized magnetic field. therapeutic efficacy this nanoplatform evaluated using models established nude mice, demonstrated remarkable ablation vivo due to photothermal/photodynamic effects. This study provides promising evidence multifunctional nanoagent might function as an efficient mediator combining photodynamic