Straightforward microwave-assisted synthesis of ultrasmall gold nanoparticles acnhored on reduced graphene oxide for enhanced antibacterial application

• DOI: 10.1007/s42452-024-06002-0
• Publication Date: 2024-06-06T06:01:44Z
• Authors: Pandji Zamzami Fa...; Eko Sri Kunarti; Nastiti Wijayanti; Sri Juari Santosa
• Keywords: 0210 nano-technology; 0104 chemical sciences

Abstract Graphene derivative materials, such as graphene oxide (GO) and reduced (rGO), have garnered significant attention from scientists for over two decades due to their distinctive characteristics versatile applications across various fields, particularly in biomedical applications. Incorporating gold nanoparticles (AuNPs) into rGO sheets rGO-Au nanocomposites further enhances its performance This study presents a rapid efficient method synthesizing ultrasmall AuNPs anchored on (rGO-Au) using microwave irradiation ascorbic acid. The optimum treatment was 4 min, ensuring the highest GO reduction degree. Structural characterization by TEM reveals architecture with (average size of 2.2 nm) distributed sheets. Interestingly, while synthesized did not exhibit any antibacterial activities against both Escherichia coli Staphylococcus aureus disk diffusion assays, it demonstrated bacteriostatic effect at remarkably low concentrations when assessed optical density measurement. effective concentration inhibit E. growth determined be 2.5 ppm, S. , 5 resulting inhibition 53.1% 50.0%, respectively. These findings provide straightforward synthesis route underscore importance AuNPs’ quantity modulating properties.