The impact of transcription-mediated replication stress on genome instability and human disease

• DOI: 10.1007/s42764-020-00021-y
• Publication Date: 2020-08-30T10:02:11Z
• Authors: Stefano Gnan; Yaqun Liu; Manuela Spagnuolo; Chun-Long Chen
• Keywords: DNA re-replication; Transcription; Pre-replication complex

Abstract DNA replication is a vital process in all living organisms. At each cell division, > 30,000 origins are activated coordinated manner to ensure the duplication of 6 billion base pairs human genome. During differentiation and development, this program must adapt changes chromatin organization gene transcription: its deregulation can challenge genome stability, which leading cause many diseases including cancers neurological disorders. Over past decade, great progress has been made better understand mechanisms regulation how challenges integrity leads disease. Growing evidence shows that transcription an essential role shaping landscape replication, while it also major source endogenous stress inducing instability. In review, we discuss current knowledge on various by impact instability