Determination of antimicrobial and modulatory activity of bacterial resistance by nettle (Cnidoscolus urens) extracts in multiresistant bacteria isolated from bovine mastitis

• DOI: 10.1007/s42770-024-01398-8
• Publication Date: 2024-05-28T21:03:57Z
• Authors: Raylson Pereira d...; André de Souza Sa...; Breno Bezerra Aragão; Cosme Nogueira da...; Kathleen Ramos De...; Magda Rhayanny As...; Luiz Alberto Lira...; Raizza Eveline Es...; Thiago Pereira Ch...; Rinaldo Aparecido...
• Keywords: Plant Leaves; Alismatales; Bacteria; Plant Extracts; Drug Resistance, Multiple, Bacterial; Animals; Cattle; Female; Microbial Sensitivity Tests; Mastitis, Bovine; Anti-Bacterial Agents; Erythromycin

The present study aimed to evaluate the antimicrobial and modulating activity of the ethanol extract obtained from the leaves, stems, and roots of Cnidoscolus urens in multiresistant bacteria. The Minimum Inhibitory Concentration (MIC) values obtained for the extracts of leaves, stems, and roots were greater than 1024 µg/mL for all isolates. In the antimicrobial resistance modulation test, the extract of the leaves of C. urens showed a better modulating effect than that of the stems and roots for gentamicin, highlighting the reduction of MIC for Escherichia coli, Lactococcus garvieae and Staphylococcus sciuri. For erythromycin, a reduction of MIC was observed in L. garvieae, Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus agalactiae. The extract from the leaves of C. urens has an important modulating effect on resistance in multiresistant bacteria, especially with gentamicin and erythromycin.