A Lindqvist-type [W6O19]2‒ organic–inorganic compound: synthesis, characterization, antibacterial activity and preliminary studies on the mechanism of action

• DOI: 10.1007/s42864-021-00073-x
• Publication Date: 2021-03-08T14:03:22Z
• Authors: Meng Zhao; Xi-Yu Zhu; Yan-Zhen Li; Jiang-Nan Chang; Ming-Xue Li; Li-Hua Ma; Xiao-Yuan Guo
• Keywords: Mechanism of Action; Semicarbazone

In this paper, a new organic–inorganic hybrid compound [Co(L)2]2[W6O19](1) (HL = 2-acetylpyridine thiosemicarbazone) was prepared and characterized. The compound 1 exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration (MIC) against Staphylococcus aureus (S. aureus, 0.06 µg·mL−1) and Escherichia coli (E. coli, 0.24 µg·mL−1), respectively. Furthermore, the potential mechanism of compound 1 was studied in detail. The potential causes of bacteria death were cell wall/membrane disruption, inhibition of intracellular respiratory chain dehydrogenases (RCD) activity, destruction of reactive oxygen species (ROS) and depletion of glutathione (GSH).