A Lindqvist-type [W6O19]2‒ organic–inorganic compound: synthesis, characterization, antibacterial activity and preliminary studies on the mechanism of action

Mechanism of Action Semicarbazone
DOI: 10.1007/s42864-021-00073-x Publication Date: 2021-03-08T14:03:22Z
ABSTRACT
In this paper, a new organic–inorganic hybrid compound [Co(L)2]2[W6O19](1) (HL = 2-acetylpyridine thiosemicarbazone) was prepared and characterized. The compound 1 exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration (MIC) against Staphylococcus aureus (S. aureus, 0.06 µg·mL−1) and Escherichia coli (E. coli, 0.24 µg·mL−1), respectively. Furthermore, the potential mechanism of compound 1 was studied in detail. The potential causes of bacteria death were cell wall/membrane disruption, inhibition of intracellular respiratory chain dehydrogenases (RCD) activity, destruction of reactive oxygen species (ROS) and depletion of glutathione (GSH).
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