Discovery of a potential bladder cancer inhibitor CHNQD-01281 by regulating EGFR and promoting infiltration of cytotoxic T cells

• DOI: 10.1007/s42995-024-00246-w
• Publication Date: 2024-08-05T12:03:52Z
• Authors: Jian-Yu Liu; Yao-Yao Jiang; Peng-Jie Li; Bo Yao; Yi-Jing Song; Ji-Xiu Gao; Gulab Said; Yang Gao; Jun-Yu Lai; Chang-Lun Shao
• Keywords: Infiltration (HVAC)

As one of the common malignancies that threaten human life, bladder cancer occurs frequently with a high mortality rate in world, due to its invasion, recurrence and drug resistance. Natural products from marine microorganisms are becoming hotspots discovery new candidate entities, especially area cancer. Brefeldin A (BFA) is natural Arf-GEFs inhibitor, but low aqueous solubility, strong toxicity, poor bioavailability, it urgent conduct structural optimization research. Herein, BFA pyridine acrylate derivative